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Eukaryotic Translation Initiation Factor 6 (EIF6)

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ITGB4BP; CAB; p27BBP; Integrin Beta 4 Binding Protein; B4 integrin interactor

Eukaryotic Translation Initiation Factor 6 (EIF6)
CCC L487
HGNC 6159
MGI 1196288
PubMed 18327211
RGD 1305373
UniProt P56537
Wiki EIF6
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains.
EIF6binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding several different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL487Hu01 Recombinant Eukaryotic Translation Initiation Factor 6 (EIF6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL487Hu01 Polyclonal Antibody to Eukaryotic Translation Initiation Factor 6 (EIF6) WB; IHC; ICC; IP.
MAL487Hu21 Monoclonal Antibody to Eukaryotic Translation Initiation Factor 6 (EIF6) WB; IHC; ICC; IP.
Assay Kits SEL487Hu ELISA Kit for Eukaryotic Translation Initiation Factor 6 (EIF6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 6 (EIF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 6 (EIF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 6 (EIF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 6 (EIF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 6 (EIF6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 6 (EIF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 6 (EIF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 6 (EIF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 6 (EIF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 6 (EIF6) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6."Proc. Natl. Acad. Sci. U.S.A. 94:14285-14290(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells."J. Biol. Chem. 272:30314-30321(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The human ITGB4BP gene is constitutively expressed in vitro, but highly modulated in vivo."Gene 266:35-43(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
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  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The beta4 integrin interactor p27(BBP/eIF6) is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly."J. Cell Biol. 144:823-837(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation of mammalian eukaryotic translation initiation factor 6 and its Saccharomyces cerevisiae homologue Tif6p: evidence that phosphorylation of Tif6p regulates its nucleocytoplasmic distribution and is required for yeast cell growth."Mol. Cell. Biol. 23:6187-6199(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly."Nature 426:579-584(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome."Genes Dev. 25:917-929(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6."J. Biol. Chem. 286:3129-3138(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]