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Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2)

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4EBP2

Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2)
CCC L482
HGNC 3289
MGI 109198
PubMed 23172145
RGD 1310824
UniProt Q13542
Wiki EIF4EBP2
EIF4EBP2 encodes a member of the eukaryotic translation initiation factor 4E binding protein family. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.Mice with both 4Ebp1 and 4Ebp2 genes knocked out are resistant to vesicular stomatitis virus infection, and this correlates with an enhanced type I interferon production in plasmacytoid dendritic cells and the expression of interferon-regulated genes in the lungs. The enhanced type I interferon response of 4Ebp1 -/- 4Ebp2 -/- double knockout mouse embryonic fibroblasts is caused by upregulation of interferon regulatory factor-7 (Irf7) mRNA translation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) ELISA Kit Customized Service Offer
  1. "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function."Nature 371:762-767(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Uterus.
  3. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface."Structure 21:2186-2196(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1."J. Pept. Sci. 17:650-657(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch."Nature 519:106-109(2015) [PubMed] [Europe PMC] [Abstract]