≡

Ets Homologous Factor (EHF)

[Edit]

ESE3; ESEJ; Epithelium-specific Ets transcription factor 3; Epithelium-Specific Ets Factor 3; ESE3 Transcription Factor; ETS domain-containing transcription factor

Ets Homologous Factor (EHF)
CCC L467
HGNC 3246
MGI 1270840
PubMed 21617703
RGD 1310282
UniProt Q9NZC4
Wiki EHF
EHF encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.Sequence analysis predicted that ESE3a encodes a 277-amino acid protein with a molecular mass of 32.3 kD, while ESE3b encodes a 300-amino acid protein with a molecular mass of 34.9 kD. The C-terminal ETS domain of ESE3 is 84% and 65% identical to the ETS domains of ESE1 and ESE2 (ELF5), respectively. Northern blot analysis detected a 5.9-kb ESE3 transcript in pancreas and prostate, with lower levels detected in kidney and colon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ets Homologous Factor (EHF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ets Homologous Factor (EHF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ets Homologous Factor (EHF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ets Homologous Factor (EHF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ets Homologous Factor (EHF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ets Homologous Factor (EHF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ets Homologous Factor (EHF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ets Homologous Factor (EHF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ets Homologous Factor (EHF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ets Homologous Factor (EHF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ets Homologous Factor (EHF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ets Homologous Factor (EHF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ets Homologous Factor (EHF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ets Homologous Factor (EHF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ets Homologous Factor (EHF) ELISA Kit Customized Service Offer
  1. "Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF."Biochem. Biophys. Res. Commun. 264:119-126(1999) [PubMed] [Europe PMC] [Abstract].
  2. "ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1."J. Biol. Chem. 275:2986-2998(2000) [PubMed] [Europe PMC] [Abstract].
  3. "The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades."J. Biol. Chem. 276:20397-20406(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  7. "Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung."Am. J. Respir. Cell Mol. Biol. 27:697-704(2002) [PubMed] [Europe PMC] [Abstract]
  8. "ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites."Biochem. Biophys. Res. Commun. 350:736-741(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs."Blood 107:3265-3270(2006) [PubMed] [Europe PMC] [Abstract]