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Dishevelled, Dsh Homolog 2 (DVL2)

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Segment polarity protein dishevelled homolog DVL-2

Dishevelled, Dsh Homolog 2 (DVL2)
CCC L454
HGNC 3086
MGI 106613
PubMed 23353182
UniProt O14641
Wiki DVL2
DVL2 encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.The cDNA sequences for DVL1, DVL2, and DVL3 were determined for the coding region of each gene and predicts proteins of 670, 736, and 716 amino acids, respectively. Comparison of the protein sequences revealed that they share 59 to 67% amino acid sequence identity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL454Hu01 Recombinant Dishevelled, Dsh Homolog 2 (DVL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL454Hu01 Polyclonal Antibody to Dishevelled, Dsh Homolog 2 (DVL2) WB; IHC; ICC/IF
Assay Kits n/a CLIA Kit for Dishevelled, Dsh Homolog 2 (DVL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dishevelled, Dsh Homolog 2 (DVL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dishevelled, Dsh Homolog 2 (DVL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dishevelled, Dsh Homolog 2 (DVL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dishevelled, Dsh Homolog 2 (DVL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dishevelled, Dsh Homolog 2 (DVL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dishevelled, Dsh Homolog 2 (DVL2) ELISA Kit Customized Service Offer
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  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins."Proc. Natl. Acad. Sci. U.S.A. 98:14889-14894(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth."J. Cell Biol. 192:993-1004(2011) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of novel rare mutations of DACT1 in human neural tube defects."Hum. Mutat. 33:1450-1455(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis."Nature 498:318-324(2013) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling." Am. J. Hum. Genet. 96:81-92(2015) [PubMed] [Europe PMC] [Abstract]
  13. "Inhibition of Wnt signaling by Dishevelled PDZ peptides."Nat. Chem. Biol. 5:217-219(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of the PDZ domains of human dishevelled 2 (homologous to Drosophila dsh)."Submitted (FEB-2009) to the PDB data bank
  15. "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]