Dishevelled, Dsh Homolog 3 (DVL3)

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Segment polarity protein dishevelled homolog DVL-3

Dishevelled, Dsh Homolog 3 (DVL3)
DVL3is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.DVL3 encodes a predicted 716-amino acid polypeptide that shows 74% nucleotide homology with human DVL1 and 71% homology with the mouse Dvl1 gene. DVL1 and DVL3 share 64% amino acid identity. PCR carried out using DNA from rodent human somatic cell hybrids and DVL3 specific primers led to the assignment of DVL3 to human chromosome 3. Hybridization of poly(A) mRNA with the DVL3 cDNA revealed a 2.9-kb transcript with abundant expression in skeletal muscle, pancreas and heart.The 5.9-kb form was abundant in fetal tissues but the 5.0-kb form was absent from these tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL453Hu01 Recombinant Dishevelled, Dsh Homolog 3 (DVL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL453Hu01 Polyclonal Antibody to Dishevelled, Dsh Homolog 3 (DVL3) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Dishevelled, Dsh Homolog 3 (DVL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dishevelled, Dsh Homolog 3 (DVL3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dishevelled, Dsh Homolog 3 (DVL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dishevelled, Dsh Homolog 3 (DVL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dishevelled, Dsh Homolog 3 (DVL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dishevelled, Dsh Homolog 3 (DVL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dishevelled, Dsh Homolog 3 (DVL3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dishevelled, Dsh Homolog 3 (DVL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dishevelled, Dsh Homolog 3 (DVL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dishevelled, Dsh Homolog 3 (DVL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dishevelled, Dsh Homolog 3 (DVL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dishevelled, Dsh Homolog 3 (DVL3) ELISA Kit Customized Service Offer
  1. "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene."Hum. Mol. Genet. 5:953-958(1996) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas."Biochem. Biophys. Res. Commun. 239:510-516(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Human dishevelled genes constitute a DHR-containing multigene family."Genomics 42:302-310(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."EMBO J. 22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis."Proc. Natl. Acad. Sci. U.S.A. 102:1927-1932(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl."Mol. Cell 37:607-619(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth."J. Cell Biol. 192:993-1004(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling." Cell 150:533-548(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Delicate analysis of post-translational modifications on Dishevelled 3."J. Proteome Res. 11:3829-3837(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Dishevelled3 is a novel arginine methyl transferase substrate."Sci. Rep. 2:805-805(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling." Am. J. Hum. Genet. 96:81-92(2015) [PubMed] [Europe PMC] [Abstract]
  19. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]