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Dopey Family, Member 2 (DOPEY2)

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C21orf5

Dopey Family, Member 2 (DOPEY2)
CCC L443
HGNC 1291
MGI 1917278
PubMed 19460634
RGD 1306097
UniProt Q9Y3R5
Wiki DOPEY2
By screening human brain cDNAs for the potential to encode proteins larger than 50 kD, Nagase et al. (1999) isolated a C21ORF5 cDNA lacking 5-prime coding sequence. The partial C21ORF5 cDNA, which they called KIAA0933, encodes a deduced 1,622-amino acid C21ORF5 polypeptide that did not show sequence similarity to known proteins. RT-PCR followed by ELISA detected DOPEY2 expression in all human tissues examined, namely brain, spinal cord, liver, pancreas, kidney, spleen, heart, lung, skeletal muscle, testis, ovary, fetal brain, and fetal liver. Within the brain, C21ORF5 expression was found in all regions tested, namely amygdala, corpus callosum, cerebellum, caudate nucleus, hippocampus, substantia nigra, subthalamic nucleus, and thalamus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopey Family, Member 2 (DOPEY2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dopey Family, Member 2 (DOPEY2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopey Family, Member 2 (DOPEY2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dopey Family, Member 2 (DOPEY2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopey Family, Member 2 (DOPEY2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopey Family, Member 2 (DOPEY2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dopey Family, Member 2 (DOPEY2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopey Family, Member 2 (DOPEY2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dopey Family, Member 2 (DOPEY2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopey Family, Member 2 (DOPEY2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopey Family, Member 2 (DOPEY2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dopey Family, Member 2 (DOPEY2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopey Family, Member 2 (DOPEY2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dopey Family, Member 2 (DOPEY2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopey Family, Member 2 (DOPEY2) ELISA Kit Customized Service Offer
  1. "C21orf5, a novel human chromosome 21 gene, has a Caenorhabditis elegans ortholog (pad-1) required for embryonic patterning."Genomics 68:30-40(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans."Mol. Microbiol. 36:1250-1264(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice."Biochem. Biophys. Res. Commun. 305:915-924(2003) [PubMed] [Europe PMC] [Abstract]
  8. "C21orf5, a human candidate gene for brain abnormalities and mental retardation in Down syndrome."Cytogenet. Genome Res. 112:16-22(2006) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]