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Derlin 1 (DERL1)

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DER1; DERtrin-1; Der1-Like Domain Family Member 1; Degradation in endoplasmic reticulum protein 1

Derlin 1 (DERL1)
CCC L423
HGNC 28454
MGI 1915069
PubMed 12975309
RGD 1311835
UniProt Q9BUN8
Wiki DERL1
Derlin-1 is a widely expressed protein, with strong signals obtained by immunoblotting from liver, spleen, pancreas, lung, thymus, and ovary. Despite the presence of Derlin-1 sequences in brain cDNA libraries, immunoreactivity was not detected in brain.Derlin-1 as an ER membrane protein essential for US11-mediated dislocation of the major histocompatibility complex (MHC) class I heavy chain from the ER to the cytosol, and showed that Derlin-1 mediates the degradation of 2 different type 1 membrane proteins, class I MHC heavy chain and US2.The central component of the complex, Derlin-1, was found to associate with different substrates as they move through the membrane. Inactivation of Derlin-1 in C. elegans caused ER stress.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Derlin 1 (DERL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Derlin 1 (DERL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Derlin 1 (DERL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Derlin 1 (DERL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Derlin 1 (DERL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Derlin 1 (DERL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Derlin 1 (DERL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Derlin 1 (DERL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Derlin 1 (DERL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Derlin 1 (DERL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Derlin 1 (DERL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Derlin 1 (DERL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Derlin 1 (DERL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Derlin 1 (DERL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Derlin 1 (DERL1) ELISA Kit Customized Service Offer
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  18. "Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u."EMBO J. 33:2492-2506(2014) [PubMed] [Europe PMC] [Abstract]