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DEAD Box Polypeptide 6 (DDX6)

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HLR2; P54; RCK; Asp-Glu-Ala-Asp Box Polypeptide 6; Probable ATP-dependent RNA helicase DDX6; ATP-dependent RNA helicase p54

DEAD Box Polypeptide 6 (DDX6)
CCC L419
HGNC 2747
MGI 104976
PubMed 23932921
UniProt P26196
Wiki DDX6
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.
DDX6 encodes a DEAD box protein. It may contribute to the cell proliferation and carcinogenesis.The predicted amino acid sequence shared 75% identity with the female germline-specific RNA helicase ME31B gene of Drosophila. Unlike ME31B, however, the new gene expressed an abundant transcript in a large number of adult tissues and its 5-prime noncoding region was found to be split in a t(11;14)(q23.3;q32.3) cell line from a diffuse large B-cell lymphoma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAD Box Polypeptide 6 (DDX6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAD Box Polypeptide 6 (DDX6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAD Box Polypeptide 6 (DDX6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAD Box Polypeptide 6 (DDX6) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAD Box Polypeptide 6 (DDX6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAD Box Polypeptide 6 (DDX6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAD Box Polypeptide 6 (DDX6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAD Box Polypeptide 6 (DDX6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAD Box Polypeptide 6 (DDX6) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAD Box Polypeptide 6 (DDX6) ELISA Kit Customized Service Offer
  1. "Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3."Nucleic Acids Res. 20:1967-1972(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations."Cancer Res. 52:6083-6087(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping."Mol. Cell 20:905-915(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies."PLoS Pathog. 2:E41-E41(2006) [PubMed] [Europe PMC] [Abstract]
  6. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  7. "LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing."Proc. Natl. Acad. Sci. U.S.A. 107:12499-12504(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."J. Virol. 86:11712-11724(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54."Acta Crystallogr. D 60:156-159(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B."Mol. Cell 33:661-668(2009) [PubMed] [Europe PMC] [Abstract]