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DEAD Box Polypeptide 5 (DDX5)

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G17P1; HLR1; HELR; HUMP68; p68; Asp-Glu-Ala-Asp Box Polypeptide 5; Probable ATP-dependent RNA helicase DDX5

DEAD Box Polypeptide 5 (DDX5)
CCC L418
HGNC 2746
MGI 105037
PubMed 17960593
RGD 619906
UniProt P17844
Wiki DDX5
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.
DDX5 encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen.DDX5 consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL418Hu01 Recombinant DEAD Box Polypeptide 5 (DDX5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL418Hu01 Polyclonal Antibody to DEAD Box Polypeptide 5 (DDX5) WB; IHC; ICC; IP.
MAL418Hu21 Monoclonal Antibody to DEAD Box Polypeptide 5 (DDX5) WB; IHC; ICC; IP.
Assay Kits SEL418Hu ELISA Kit for DEAD Box Polypeptide 5 (DDX5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAD Box Polypeptide 5 (DDX5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAD Box Polypeptide 5 (DDX5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAD Box Polypeptide 5 (DDX5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAD Box Polypeptide 5 (DDX5) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAD Box Polypeptide 5 (DDX5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAD Box Polypeptide 5 (DDX5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAD Box Polypeptide 5 (DDX5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAD Box Polypeptide 5 (DDX5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAD Box Polypeptide 5 (DDX5) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAD Box Polypeptide 5 (DDX5) ELISA Kit Customized Service Offer
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  9. "Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha."Mol. Cell. Biol. 19:5363-5372(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase."Exp. Cell Res. 257:272-280(2000) [PubMed] [Europe PMC] [Abstract]
  11. "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA."EMBO J. 20:1341-1352(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells."Nucleic Acids Res. 31:1470-1480(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300."Oncogene 22:151-156(2003) [PubMed] [Europe PMC] [Abstract]
  15. "The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner."BMC Mol. Biol. 5:11-11(2004) [PubMed] [Europe PMC] [Abstract]
  16. "The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor."EMBO J. 24:543-553(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  18. "The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation."Dev. Cell 11:547-560(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
  20. "SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1."Oncogene 26:5866-5876(2007) [PubMed] [Europe PMC] [Abstract]
  21. "The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer."Cancer Res. 68:7938-7946(2008) [PubMed] [Europe PMC] [Abstract]
  22. "p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation."J. Cell. Biochem. 103:1438-1451(2008) [PubMed] [Europe PMC] [Abstract]
  23. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  24. "The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer."Oncogene 28:4053-4064(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential."Biochemistry 49:1-10(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  29. "RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site."Mol. Cell. Biol. 31:1812-1821(2011) [PubMed] [Europe PMC] [Abstract]
  30. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  31. "Comparative structural analysis of human DEAD-box RNA helicases."PLoS ONE 5:E12791-E12791(2010) [PubMed] [Europe PMC] [Abstract]