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DEAD Box Polypeptide 3, X-Linked (DDX3X)

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DBX; DDX14; DDX3; HLP2; Asp-Glu-Ala-Asp Box Polypeptide 3; ATP-dependent RNA helicase DDX3X; Helicase-like protein 2

DEAD Box Polypeptide 3, X-Linked (DDX3X)
CCC L415
HGNC 2745
MGI 103064
PubMed 18583960
RGD 1564771
UniProt O00571
Wiki DDX3X
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX3X encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAD Box Polypeptide 3, X-Linked (DDX3X) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAD Box Polypeptide 3, X-Linked (DDX3X) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAD Box Polypeptide 3, X-Linked (DDX3X) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAD Box Polypeptide 3, X-Linked (DDX3X) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAD Box Polypeptide 3, X-Linked (DDX3X) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAD Box Polypeptide 3, X-Linked (DDX3X) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAD Box Polypeptide 3, X-Linked (DDX3X) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAD Box Polypeptide 3, X-Linked (DDX3X) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAD Box Polypeptide 3, X-Linked (DDX3X) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAD Box Polypeptide 3, X-Linked (DDX3X) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAD Box Polypeptide 3, X-Linked (DDX3X) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAD Box Polypeptide 3, X-Linked (DDX3X) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAD Box Polypeptide 3, X-Linked (DDX3X) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAD Box Polypeptide 3, X-Linked (DDX3X) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAD Box Polypeptide 3, X-Linked (DDX3X) ELISA Kit Customized Service Offer
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  2. "Hepatitis C virus core protein interacts with a human DEAD box protein DDX3."Virology 257:330-340(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Functional coherence of the human Y chromosome."Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility complex class I proteins bind peptides with a blocked NH(2) terminus in vivo."J. Exp. Med. 191:2083-2092(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function."Cell 119:381-392(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor."Cancer Res. 66:6579-6588(2006) [PubMed] [Europe PMC] [Abstract]
  11. "DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control."Oncogene 25:1991-2003(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity."Proteins 67:1128-1137(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment."RNA 13:116-128(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of an antiapoptotic protein complex at death receptors."Cell Death Differ. 15:1887-1900(2008) [PubMed] [Europe PMC] [Abstract]
  15. "The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response."EMBO J. 27:2135-2146(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation."EMBO J. 27:2147-2157(2008) [PubMed] [Europe PMC] [Abstract]
  17. "TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules."Hum. Mol. Genet. 17:3055-3074(2008) [PubMed] [Europe PMC] [Abstract]
  18. "The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control."Mol. Biol. Cell 19:3847-3858(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Human DDX3 functions in translation and interacts with the translation initiation factor eIF3."Nucleic Acids Res. 36:4708-4718(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein."Oncogene 27:700-714(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Oncogenic role of DDX3 in breast cancer biogenesis."Oncogene 27:3912-3922(2008) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs."RNA 15:104-115(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  25. "DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential."Eur. J. Immunol. 40:940-948(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3."J. Gen. Virol. 91:2080-2090(2010) [PubMed] [Europe PMC] [Abstract]
  27. "DDX3 regulates cell growth through translational control of cyclin E1."Mol. Cell. Biol. 30:5444-5453(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction."PLoS ONE 5:E14258-E14258(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion."PLoS Pathog. 6:E1000986-E1000986(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  32. "A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication."PLoS ONE 6:E19810-E19810(2011) [PubMed] [Europe PMC] [Abstract]
  33. "DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation."Proc. Natl. Acad. Sci. U.S.A. 108:12007-12012(2011) [PubMed] [Europe PMC] [Abstract]
  34. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  35. "Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response."Biochem. J. 441:119-129(2012) [PubMed] [Europe PMC] [Abstract]
  36. "The DEAD-box RNA helicase DDX3 interacts with DDX5, co-localizes with it in the cytoplasm during the G2/M phase of the cycle, and affects its shuttling during mRNP export."J. Cell. Biochem. 113:985-996(2012) [PubMed] [Europe PMC] [Abstract]
  37. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  38. "The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes."Nucleic Acids Res. 40:4998-5011(2012) [PubMed] [Europe PMC] [Abstract]
  39. "DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs."EMBO J. 31:3745-3756(2012) [PubMed] [Europe PMC] [Abstract]
  40. "Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation."Mol. Cell. Biol. 33:2004-2015(2013) [PubMed] [Europe PMC] [Abstract]
  41. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  42. "Expression, purification, crystallization and preliminary X-ray diffraction analysis of the DDX3 RNA helicase domain."Acta Crystallogr. F 63:283-286(2007) [PubMed] [Europe PMC] [Abstract]
  43. "Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP."J. Mol. Biol. 372:150-159(2007) [PubMed] [Europe PMC] [Abstract]
  44. "Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7."Structure 17:1528-1537(2009) [PubMed] [Europe PMC] [Abstract]
  45. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]