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DEAD Box Polypeptide 1 (DDX1)

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DBP-RB; UKVH5d; Asp-Glu-Ala-Asp Box Polypeptide 1; DEAD box protein retinoblastoma; ATP-dependent RNA helicase DDX1

DEAD Box Polypeptide 1 (DDX1)
CCC L414
HGNC 2734
MGI 2144727
PubMed 21703541
RGD 619903
UniProt Q92499
Wiki DDX1
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.
DDX1 encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAD Box Polypeptide 1 (DDX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAD Box Polypeptide 1 (DDX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAD Box Polypeptide 1 (DDX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAD Box Polypeptide 1 (DDX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAD Box Polypeptide 1 (DDX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAD Box Polypeptide 1 (DDX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAD Box Polypeptide 1 (DDX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAD Box Polypeptide 1 (DDX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAD Box Polypeptide 1 (DDX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAD Box Polypeptide 1 (DDX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAD Box Polypeptide 1 (DDX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAD Box Polypeptide 1 (DDX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAD Box Polypeptide 1 (DDX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAD Box Polypeptide 1 (DDX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAD Box Polypeptide 1 (DDX1) ELISA Kit Customized Service Offer
  1. "Amplification of a DEAD box protein gene in retinoblastoma cell lines."Proc. Natl. Acad. Sci. U.S.A. 90:7578-7582(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA."Mol. Biol. Cell 12:3046-3059(2001) [PubMed] [Europe PMC] [Abstract]
  5. "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K."J. Biol. Chem. 277:40403-40409(2002) [PubMed] [Europe PMC] [Abstract]
  6. "A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev."Virology 330:471-480(2004) [PubMed] [Europe PMC] [Abstract]
  7. "MBNL1 associates with YB-1 in cytoplasmic stress granules."J. Neurosci. Res. 86:1994-2002(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A role for DEAD box 1 at DNA double-strand breaks."Mol. Cell. Biol. 28:6413-6425(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription."J. Cell. Biochem. 106:296-305(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication."J. Virol. 84:8571-8583(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "HSPC117 is the essential subunit of a human tRNA splicing ligase complex."Science 331:760-764(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors."Nature 511:104-107(2014) [PubMed] [Europe PMC] [Abstract]
  18. "hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex."PLoS ONE 9:E90957-E90957(2014) [PubMed] [Europe PMC] [Abstract]