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DNA Cross Link Repair 1B Protein (DCLRE1B)

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SNM1B; 5' exonuclease Apollo

DNA Cross Link Repair 1B Protein (DCLRE1B)
CCC L409
HGNC 17641
MGI 2156057
PubMed 21671477
RGD 1310343
UniProt Q9H816
Wiki DCLRE1B
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links. The human and mouse SNM1B proteins share high similarity with one another, but less similarity with S. cerevisiae Snm1.The deduced protein contains 532 amino acids and shares similarity with S. cerevisiae Pso2 only in its N terminus. SNM1B-depleted cells showed an elevated rate of chromosome breakage.
SNM1B may be involved in homologous recombination repair of double-strand breaks arising as intermediates during repair of interstrand cross-links.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Cross Link Repair 1B Protein (DCLRE1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Cross Link Repair 1B Protein (DCLRE1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Cross Link Repair 1B Protein (DCLRE1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Cross Link Repair 1B Protein (DCLRE1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Cross Link Repair 1B Protein (DCLRE1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Cross Link Repair 1B Protein (DCLRE1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Cross Link Repair 1B Protein (DCLRE1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Cross Link Repair 1B Protein (DCLRE1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Cross Link Repair 1B Protein (DCLRE1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Cross Link Repair 1B Protein (DCLRE1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Cross Link Repair 1B Protein (DCLRE1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Cross Link Repair 1B Protein (DCLRE1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Cross Link Repair 1B Protein (DCLRE1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Cross Link Repair 1B Protein (DCLRE1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Cross Link Repair 1B Protein (DCLRE1B) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation."Mol. Cell. Biol. 24:10733-10741(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation."Oncogene 23:8611-8618(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase."Curr. Biol. 16:1295-1302(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair."Curr. Biol. 16:1303-1310(2006) [PubMed] [Europe PMC] [Abstract]
  8. "hSnm1B is a novel telomere-associated protein."J. Biol. Chem. 281:15033-15036(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation."DNA Repair 7:1192-1201(2008) [PubMed] [Europe PMC] [Abstract]
  10. "The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2."J. Biol. Chem. 283:23671-23676(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links."Oncogene 27:5045-5056(2008) [PubMed] [Europe PMC] [Abstract]
  12. "SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint."Cell Cycle 8:628-638(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Evidence for hSNM1B/Apollo functioning in the HSP70 mediated DNA damage response."Cell Cycle 8:1725-1732(2009) [PubMed] [Europe PMC] [Abstract]
  14. "TRF2 and Apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage." Cell 142:230-242(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome."Proc. Natl. Acad. Sci. U.S.A. 107:10097-10102(2010) [PubMed] [Europe PMC] [Abstract]
  16. "A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins."Science 319:1092-1096(2008) [PubMed] [Europe PMC] [Abstract]