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Cytochrome P450 4F2 (CYP4F2)

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CPF2; Leukotriene-B(4)omega-hydroxylase 1; Cytochrome P450 Family 4 Subfamily F Polypeptide 2; 20-hydroxyeicosatetraenoic acid synthase; Arachidonic acid omega-hydroxylase

Cytochrome P450 4F2 (CYP4F2)
CCC L399
HGNC 2645
MGI 2158641
PubMed 23650179
RGD 708365
UniProt P78329
Wiki CYP4F2
CYP4F2 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.The CYP4F2 gene contains at least 13 exons, with its open reading frame being encoded from exon II to exon XIII. Exon I includes 49 bp of a 5-prime untranslated sequence. The structure of this gene was found to be very similar to that of CYP4F3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL399Hu01 Recombinant Cytochrome P450 4F2 (CYP4F2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL399Hu01 Polyclonal Antibody to Cytochrome P450 4F2 (CYP4F2) WB; IHC; ICC; IP.
Assay Kits SEL399Hu ELISA Kit for Cytochrome P450 4F2 (CYP4F2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 4F2 (CYP4F2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 4F2 (CYP4F2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 4F2 (CYP4F2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 4F2 (CYP4F2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 4F2 (CYP4F2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 4F2 (CYP4F2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 4F2 (CYP4F2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 4F2 (CYP4F2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 4F2 (CYP4F2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 4F2 (CYP4F2) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver."FEBS Lett. 348:70-74(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene."DNA Cell Biol. 18:723-730(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Promoter activity and regulation of the CYP4F2 leukotriene B4 omega hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells."Arch. Biochem. Biophys. 378:364-376(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4."Arch. Biochem. Biophys. 359:89-98(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11."J. Biol. Chem. 275:4118-4126(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Functional polymorphism in human CYP4F2 decreases 20-HETE production."Physiol. Genomics 30:74-81(2007) [PubMed] [Europe PMC] [Abstract]
  10. "The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure."Hypertension 52:373-380(2008) [PubMed] [Europe PMC] [Abstract]
  11. "CYP4F2 genetic variant alters required warfarin dose."Blood 111:4106-4112(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Pharmacogenetic relevance of CYP4F2 V433M polymorphism on acenocoumarol therapy."Blood 113:4977-4979(2009) [PubMed] [Europe PMC] [Abstract]
  13. "CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant."Mol. Pharmacol. 75:1337-1346(2009) [PubMed] [Europe PMC] [Abstract]
  14. "CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population."Pharmacogenomics 10:261-266(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements."J. Hum. Genet. 55:582-589(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Common variants of cytochrome P450 4F2 exhibit altered vitamin E-{omega}-hydroxylase specific activity."J. Nutr. 140:1901-1906(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis." Clin. Pharmacol. Ther. 92:746-756(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Cytochrome P450-dependent catabolism of vitamin K: omega-hydroxylation catalyzed by human CYP4F2 and CYP4F11."Biochemistry 52:8276-8285(2013) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]