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CXXC Finger Protein 1 (CXXC1)

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SPP1; CFP1; CGBP; PCCX1; PHF18; hCGBP; CpG-Binding Protein; PHD finger and CXXC domain-containing protein 1

CXXC Finger Protein 1 (CXXC1)
CCC L391
HGNC 24343
MGI 1921572
PubMed 10799292
RGD 1310755
UniProt Q9P0U4
Wiki CXXC1
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression. The deduced 656-amino acid protein has a calculated molecular mass of 76 kD. CGBP contains an N-terminal PHD domain, followed by a CXXC domain, a central basic region, a coiled-coil domain, and an imperfect PHD domain near its C terminus. Northern blot analysis detected a 2.6-kb CGBP transcript in all tissues examined. Western blot analysis of nuclear extracts of a myeloid cell line detected endogenous CGBP at an apparent molecular mass of 88 kD.CGBP failed to bind oligonucleotides in which the CpG motif was mutated or methylated, and it did not bind single-stranded DNA or RNA probes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CXXC Finger Protein 1 (CXXC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CXXC Finger Protein 1 (CXXC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CXXC Finger Protein 1 (CXXC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CXXC Finger Protein 1 (CXXC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CXXC Finger Protein 1 (CXXC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CXXC Finger Protein 1 (CXXC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CXXC Finger Protein 1 (CXXC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CXXC Finger Protein 1 (CXXC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CXXC Finger Protein 1 (CXXC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CXXC Finger Protein 1 (CXXC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CXXC Finger Protein 1 (CXXC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CXXC Finger Protein 1 (CXXC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CXXC Finger Protein 1 (CXXC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CXXC Finger Protein 1 (CXXC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CXXC Finger Protein 1 (CXXC1) ELISA Kit Customized Service Offer
  1. "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1."Mol. Cell. Biol. 20:2108-2121(2000) [PubMed] [Europe PMC] [Abstract]
  2. "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis."Biochem. Biophys. Res. Commun. 271:305-310(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of the DNA binding domain of CpG-binding protein."J. Biol. Chem. 276:44669-44676(2001) [PubMed] [Europe PMC] [Abstract]
  8. "CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals."J. Biol. Chem. 277:42259-42267(2002) [PubMed] [Europe PMC] [Abstract]
  9. "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex."J. Biol. Chem. 280:41725-41731(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex."J. Biol. Chem. 282:13419-13428(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."Mol. Cell. Biol. 28:609-618(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation."Cell 151:1097-1112(2012) [PubMed] [Europe PMC] [Abstract]
  17. "The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain."Nat. Commun. 2:227-227(2011) [PubMed] [Europe PMC] [Abstract]