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CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2)

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BRUNOL3; ETR-3; NAPOR; CELF2; Bruno-like protein 3; CUG-BP-and ETR-3-like factor 2; Neuroblastoma apoptosis-related RNA-binding protein; ELAV-type RNA-binding protein 3

CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2)
CCC L389
HGNC 2550
MGI 1338822
PubMed 12535526
RGD 68347
UniProt O95319
Wiki CUGBP2
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Mouse Etr3 was found to have a molecular weight of 50 kD and displayed a high level of homology with CUGBP protein. Organization of the RNA-binding domains within the Etr3 molecule was similar to one within CUGBP. A study of mouse Etr3 RNA-binding activity showed that mouse Etr3 bound to (CUG)8 repeats; sequence analysis indicated the presence of several CUG repeats within the mouse Etr3 mRNA. The authors found that in humans ETR3 mRNA was highly expressed in the heart but was undetectable in other tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CUG Triplet Repeat, RNA Binding Protein 2 (CUGBP2) ELISA Kit Customized Service Offer
  1. "Fluorescent differential display analysis of gene expression in apoptotic neuroblastoma cells."Gene 223:21-31(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein."Gene 237:135-142(1999) [PubMed] [Europe PMC] [Abstract]
  3. "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator."J. Biol. Chem. 275:28583-28592(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia."Genomics 74:396-401(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy."Nucleic Acids Res. 24:4407-4414(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor."J. Biol. Chem. 276:47338-47351(2001) [PubMed] [Europe PMC] [Abstract]
  10. "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing."Mol. Cell. Biol. 21:1285-1296(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing."Mol. Cell 9:649-658(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein."RNA 9:443-456(2003) [PubMed] [Europe PMC] [Abstract]
  13. "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo."Nucleic Acids Res. 32:1232-1241(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of putative new splicing targets for ETR-3 using sequences identified by systematic evolution of ligands by exponential enrichment."Mol. Cell. Biol. 25:879-887(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of CELF splicing activation and repression domains in vivo."Nucleic Acids Res. 33:2769-2780(2005) [PubMed] [Europe PMC] [Abstract]
  16. "ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I."J. Neurosci. Res. 84:852-859(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]