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CCCTC Binding Factor Like Protein (CTCFL)

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CTCF-T; BORIS; CT27; Brother Of Regulator Of Imprinted Sites; Cancer/Testis Antigen 27; Transcriptional repressor CTCFL; CTCF paralog

CCCTC Binding Factor Like Protein (CTCFL)
CCC L386
HGNC 16234
MGI 3652571
PubMed 22168535
UniProt Q8NI51
Wiki CTCFL
CTCF and CTCFL are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation.
The deduced 663-amino acid protein contains 11 central ZFs like CTCF, but it has unique N and C termini. EMSA analysis showed an interaction with testis DNA. Northern blot and RT-PCR analyses revealed that expression of CTCFL is testis-specific in humans and mice. Immunohistochemical and Western blot analyses showed expression of an approximately 83-kD protein primarily in the cytoplasm of spermatocytes, with some nuclear expression detected. CTCF, on the other hand, was restricted to the nucleus and was expressed in somatic cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCCTC Binding Factor Like Protein (CTCFL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCCTC Binding Factor Like Protein (CTCFL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCCTC Binding Factor Like Protein (CTCFL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCCTC Binding Factor Like Protein (CTCFL) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCCTC Binding Factor Like Protein (CTCFL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCCTC Binding Factor Like Protein (CTCFL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCCTC Binding Factor Like Protein (CTCFL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCCTC Binding Factor Like Protein (CTCFL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCCTC Binding Factor Like Protein (CTCFL) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCCTC Binding Factor Like Protein (CTCFL) ELISA Kit Customized Service Offer
  1. "BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma." Proc. Natl. Acad. Sci. U.S.A. 99:6806-6811(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation."PLoS Biol. 4:E355-E355(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors."Nucleic Acids Res. 35:7372-7388(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer."Semin. Cancer Biol. 12:399-414(2002) [PubMed] [Europe PMC] [Abstract]
  8. "DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation."Cancer Res. 68:2726-2735(2008) [PubMed] [Europe PMC] [Abstract]
  9. "BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression."Mol. Cell. Biol. 28:6720-6729(2008) [PubMed] [Europe PMC] [Abstract]