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Crumbs Homolog 3 (CRB3)

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Crumbs Homolog 3 (CRB3)
CCC L377
HGNC 20237
MGI 2670904
PubMed 23439680
RGD 1565035
UniProt Q9BUF7
Wiki CRB3
CRB3 encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
The CRB3 cDNA encodes a deduced 120-amino acid protein with a putative signal peptide in the first 20 amino acids, a putative extracellular N-glycosylation site, and a transmembrane domain. The intracellular domain contains a conserved band-4.1 superfamily-binding site and a Pals PDZ domain-binding site, as found in Drosophila Crumbs and human CRB1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crumbs Homolog 3 (CRB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crumbs Homolog 3 (CRB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crumbs Homolog 3 (CRB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crumbs Homolog 3 (CRB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crumbs Homolog 3 (CRB3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crumbs Homolog 3 (CRB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crumbs Homolog 3 (CRB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crumbs Homolog 3 (CRB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crumbs Homolog 3 (CRB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crumbs Homolog 3 (CRB3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crumbs Homolog 3 (CRB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crumbs Homolog 3 (CRB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crumbs Homolog 3 (CRB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crumbs Homolog 3 (CRB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crumbs Homolog 3 (CRB3) ELISA Kit Customized Service Offer
  1. "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)."Gene 302:21-29(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells."J. Cell Sci. 116:2895-2906(2003) [PubMed] [Europe PMC] [Abstract]
  6. "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells."Mol. Biol. Cell 15:1324-1333(2004) [PubMed] [Europe PMC] [Abstract]