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COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2)

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CSN2; ALIEN; SGN2; TRIP15; Signalosome subunit 2; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15

COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2)
CCC L372
HGNC 30747
MGI 1330276
PubMed 7776974
RGD 628791
UniProt P61201
Wiki COPS2
The thyroid hormone receptors (TRs) are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. They must specifically interact with a number of proteins as they progress from their initial translation and nuclear translocation to heterodimerization with retinoid X receptors (RXRs), functional interactions with other transcription factors and the basic transcriptional apparatus, and eventually, degradation.
TRIP15 interacted with rat Thrb only in the absence of thyroid hormone. In contrast, it interacted with RXR-alpha (RXRA) only in the presence of 9-cis-retinoic acid. TRIP15 did not interact with the glucocorticoid receptor (NR3C1) under any condition.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 2 (COPS2) ELISA Kit Customized Service Offer
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  7. "Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome."J. Biol. Chem. 275:39081-39089(2000) [PubMed] [Europe PMC] [Abstract]
  8. "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system."EMBO J. 20:1630-1639(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome."Science 292:1382-1385(2001) [PubMed] [Europe PMC] [Abstract]
  10. "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage."Cell 113:357-367(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome."EMBO J. 22:1302-1312(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry."J. Proteome Res. 7:4914-4925(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]