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COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3)

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SGN3; CSN3; Signalosome subunit 3; JAB1-containing signalosome subunit 3

COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3)
CCC L371
HGNC 2239
MGI 1349409
PubMed 9535219
RGD 1303002
UniProt Q9UNS2
Wiki COPS3
COPS3 possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.Sequence analysis predicted that COPS3 is a 403-amino acid protein which contains regions with homology to the 26S proteasome S3 regulatory subunit. Autoradiographic analysis showed that the complex phosphorylates JUN, IKBA, and the C-terminal part of the p105 precursor of NFKB. The 26S proteasome is not a phosphorylation target, although immunofluorescence microscopy demonstrated that the 450-kD complex has a cytosolic localization, concentrated around the nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 3 (COPS3) ELISA Kit Customized Service Offer
  1. "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits."FASEB J. 12:469-478(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the Smith-Magenis syndrome critical region in 17p11.2."Genomics 57:180-182(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  7. , Submitted (OCT-2005) to UniProtKB
  8. "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system."EMBO J. 20:1630-1639(2001) [PubMed] [Europe PMC] [Abstract]
  9. "CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation."FEBS Lett. 499:133-136(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome."Science 292:1382-1385(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome."FEBS Lett. 527:15-21(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage."Cell 113:357-367(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome."EMBO J. 22:1302-1312(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation."Oncogene 22:5358-5361(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Amplification and overexpression of genes in 17p11.2 approximately p12 in osteosarcoma."Cancer Genet. Cytogenet. 153:77-80(2004) [PubMed] [Europe PMC] [Abstract]
  16. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry."J. Proteome Res. 7:4914-4925(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  24. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]