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COMM Domain Containing Protein 1 (COMMD1)

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MURR1; C2orf5

COMM Domain Containing Protein 1 (COMMD1)
CCC L369
HGNC 23024
MGI 109474
PubMed 20237237
UniProt Q8N668
Wiki COMMD1
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B signaling. The predicted human, mouse, and canine proteins share 86 to 87% amino acid identity. Northern blot analysis of human tissues using a canine Murr1 probe revealed highest expression in liver, with lower expression in heart, skeletal muscle, kidney, and placenta.This inhibition was mediated in part through its ability to inhibit basal and cytokine-stimulated nuclear factor NF-kappa-B activity. Knockdown of MURR1 increased NF-kappa-B activity and decreased IKBA concentrations by facilitating phospho-IKBA degradation by the proteasome. MURR1 was detected in CD4+ T cells, and RNA-mediated interference of MURR1 in primary resting CD4+ lymphocytes increased HIV-1 replication.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COMM Domain Containing Protein 1 (COMMD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COMM Domain Containing Protein 1 (COMMD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COMM Domain Containing Protein 1 (COMMD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COMM Domain Containing Protein 1 (COMMD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for COMM Domain Containing Protein 1 (COMMD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COMM Domain Containing Protein 1 (COMMD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COMM Domain Containing Protein 1 (COMMD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COMM Domain Containing Protein 1 (COMMD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COMM Domain Containing Protein 1 (COMMD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for COMM Domain Containing Protein 1 (COMMD1) ELISA Kit Customized Service Offer
  1. "The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis."J. Hepatol. 38:164-168(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients."J. Mol. Med. 82:629-634(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a new copper metabolism gene by positional cloning in a purebred dog population."Hum. Mol. Genet. 11:165-173(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein."J. Biol. Chem. 278:41593-41596(2003) [PubMed] [Europe PMC] [Abstract]
  8. "A novel role for XIAP in copper homeostasis through regulation of MURR1."EMBO J. 23:244-254(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of Murr1 as a regulator of the human delta epithelial sodium channel."J. Biol. Chem. 279:5429-5434(2004) [PubMed] [Europe PMC] [Abstract]
  10. "COMMD proteins, a novel family of structural and functional homologs of MURR1."J. Biol. Chem. 280:22222-22232(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of COMMD protein-protein interactions in NF-kappaB signalling."Biochem. J. 398:63-71(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization and copper binding properties of human COMMD1 (MURR1)."Biochemistry 46:3116-3128(2007) [PubMed] [Europe PMC] [Abstract]
  13. "COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase."EMBO J. 26:436-447(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1."J. Biol. Chem. 283:11453-11460(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate."J. Biol. Chem. 284:696-707(2009) [PubMed] [Europe PMC] [Abstract]
  17. "COMMD1 downregulates the epithelial sodium channel through Nedd4-2."Am. J. Physiol. 298:F1445-F1456(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination."Cancer Res. 70:139-149(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Cu,Zn superoxide dismutase maturation and activity are regulated by COMMD1."J. Biol. Chem. 285:28991-29000(2010) [PubMed] [Europe PMC] [Abstract]
  20. "COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion."J. Clin. Invest. 120:2119-2130(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells."Mol. Cancer Res. 8:119-130(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "COMMD1 regulates the delta epithelial sodium channel (deltaENaC) through trafficking and ubiquitination."Biochem. Biophys. Res. Commun. 411:506-511(2011) [PubMed] [Europe PMC] [Abstract]
  24. "COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding."J. Biol. Chem. 286:32355-32365(2011) [PubMed] [Europe PMC] [Abstract]
  25. "COMMD1-mediated ubiquitination regulates CFTR trafficking."PLoS ONE 6:E18334-E18334(2011) [PubMed] [Europe PMC] [Abstract]
  26. "COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination."Am. J. Physiol. 305:C133-C146(2013) [PubMed] [Europe PMC] [Abstract]
  27. "Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel."Am. J. Physiol. 305:F80-F89(2013) [PubMed] [Europe PMC] [Abstract]
  28. "CCDC22 deficiency in humans blunts activation of proinflammatory NF-kappaB signaling."J. Clin. Invest. 123:2244-2256(2013) [PubMed] [Europe PMC] [Abstract]
  29. "p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-kappaB subunit."J. Cell Sci. 127:3659-3665(2014) [PubMed] [Europe PMC] [Abstract]
  30. "COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A." Mol. Biol. Cell 26:91-103(2015) [PubMed] [Europe PMC] [Abstract]
  31. "Solution structure of the COMMD1 N-terminal domain."J. Mol. Biol. 365:715-721(2007) [PubMed] [Europe PMC] [Abstract]