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CCR4 NOT Transcription Complex Subunit 3 (CNOT3)

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LENG2; NOT3; NOT3H; Negative Regulator Of Transcription 3; CCR4-associated factor 3; Leukocyte receptor cluster member 2

CCR4 NOT Transcription Complex Subunit 3 (CNOT3)
CCC L366
HGNC 7879
MGI 2385261
PubMed 23144630
RGD 1304771
UniProt O75175
Wiki CNOT3
Comparison of the sequence of the human NOT3 protein to that of the 836-amino acid yeast NOT3 protein revealed 24% overall identity, with 41% identity in the first 232 amino acids. Compared to human NOT3, yeast NOT3 has a C-terminal extension. The 560-amino acid yeast NOT5 protein is highly similar to yeast NOT3 in its N-terminal region.
The human NOT3 protein shares 24% overall sequence identity with yeast NOT5, with 39% identity in the N-terminal 212 residues. The C-terminal domain of human NOT3 is extremely rich in proline and serine residues. Both recombinant human NOT3 protein expressed in mammalian cells and endogenous NOT3 from HeLa cells migrated as 120-kD proteins in SDS-polyacrylamide gels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 3 (CNOT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 3 (CNOT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 3 (CNOT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 3 (CNOT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 3 (CNOT3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 3 (CNOT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 3 (CNOT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 3 (CNOT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 3 (CNOT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 3 (CNOT3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 3 (CNOT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 3 (CNOT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 3 (CNOT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 3 (CNOT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 3 (CNOT3) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits."Nucleic Acids Res. 28:809-817(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3."Biochem. Biophys. Res. Commun. 296:1097-1103(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex."J. Biol. Chem. 279:10848-10854(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Human Ccr4-Not complexes contain variable deadenylase subunits."Biochem. J. 422:443-453(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death."Genes Cells 16:368-379(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression."Biochem. Biophys. Res. Commun. 419:268-273(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation."Stem Cells 30:910-922(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]