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CCR4 NOT Transcription Complex Subunit 2 (CNOT2)

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CDC36; HSPC131; NOT2; NOT2H; CCR4-associated factor 2

CCR4 NOT Transcription Complex Subunit 2 (CNOT2)
CCC L365
HGNC 7878
MGI 1919318
PubMed 22367759
RGD 1311672
UniProt Q9NZN8
Wiki CNOT2
NOT2 protein shares 26% overall sequence identity with the 191-amino acid yeast NOT2 protein. Compared to yeast NOT2, human NOT2 has an N-terminal extension. Human NOT2 contains an N-terminal putative bipartite nuclear localization signal. recombinant human NOT2 can interact with yeast NOT1 and an N-terminally truncated human NOT1 protein; it did not significantly interact with human NOT3 or yeast CCR4. Northern blot analysis detected a 3.2-kb NOT2 transcript in all human tissues examined, namely brain, heart, lung, liver, kidney, small intestine, colon, spleen, thymus, peripheral blood leukocytes, skeletal muscle, and placenta. Like the expression of human NOT1, NOT3, and CALIF, NOT2 expression was high in brain, kidney, and placenta and very low in skeletal muscle and colon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 2 (CNOT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 2 (CNOT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 2 (CNOT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 2 (CNOT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 2 (CNOT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 2 (CNOT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 2 (CNOT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 2 (CNOT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 2 (CNOT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 2 (CNOT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 2 (CNOT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 2 (CNOT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 2 (CNOT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 2 (CNOT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 2 (CNOT2) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits."Nucleic Acids Res. 28:809-817(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex."J. Biol. Chem. 279:10848-10854(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex."Biochem. J. 398:461-467(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Human Ccr4-Not complexes contain variable deadenylase subunits."Biochem. J. 422:443-453(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death."Genes Cells 16:368-379(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation."Stem Cells 30:910-922(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]