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Centromere/Kinetochore Protein Zeste White 10 (ZW10)

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HZW10; KNTC1AP

Centromere/Kinetochore Protein Zeste White 10 (ZW10)
CCC L358
HGNC 13194
MGI 1349478
PubMed 20696768
RGD 1309197
UniProt O43264
Wiki ZW10
ZW10encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.
Zw10 may act at the kinetochore as part of a tension-sensing checkpoint that renders anaphase onset dependent upon bipolar tension exerted across all centromeres. Overall, the predicted ZW10 proteins of Drosophila, C. elegans, human, and Arabidopsis share 17 to 26% identity. Northern blot analysis revealed that the human ZW10 gene was expressed as an approximately 2.9-kb mRNA in various human cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere/Kinetochore Protein Zeste White 10 (ZW10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere/Kinetochore Protein Zeste White 10 (ZW10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere/Kinetochore Protein Zeste White 10 (ZW10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere/Kinetochore Protein Zeste White 10 (ZW10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere/Kinetochore Protein Zeste White 10 (ZW10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere/Kinetochore Protein Zeste White 10 (ZW10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere/Kinetochore Protein Zeste White 10 (ZW10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere/Kinetochore Protein Zeste White 10 (ZW10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere/Kinetochore Protein Zeste White 10 (ZW10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere/Kinetochore Protein Zeste White 10 (ZW10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere/Kinetochore Protein Zeste White 10 (ZW10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere/Kinetochore Protein Zeste White 10 (ZW10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere/Kinetochore Protein Zeste White 10 (ZW10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere/Kinetochore Protein Zeste White 10 (ZW10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere/Kinetochore Protein Zeste White 10 (ZW10) ELISA Kit Customized Service Offer
  1. "Conservation of the centromere/kinetochore protein ZW10."J. Cell Biol. 138:1289-1301(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (JUL-2007) to UniProtKB
  6. "The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore."J. Cell Sci. 114:3103-3114(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions."Mol. Biol. Cell 14:1379-1391(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion."EMBO J. 23:3216-3226(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes."Gene 331:33-40(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling."J. Biol. Chem. 279:54590-54598(2004) [PubMed] [Europe PMC] [Abstract]
  12. "ZW10 links mitotic checkpoint signaling to the structural kinetochore."J. Cell Biol. 169:49-60(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control."Oncogene 25:6901-6914(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]