C-Type Lectin Domain Family 2, Member B (CLEC2B)

CLEC2B encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

The predicted 149-amino acid AICL protein is a type II membrane protein, with a C-terminal extracellular C-type lectin domain, a transmembrane region, and a very short N-terminal cytoplasmic domain. AICL has a molecular mass of approximately 17 kD. Transcription of AICL was transiently upregulated during lymphocyte activation by PMA, with kinetics similar to those of CD69.