Cell Death Inducing DFFA Like Effector A (CIDEA)

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CIDE-A; Cell death activator CIDE-A

Cell Death Inducing DFFA Like Effector A (CIDEA)
CIDEA encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Two alternative transcripts encoding different isoforms have been identified.Mutant analysis revealed that the C-terminal region of CIDEA was necessary and sufficient for killing, whereas the region with homology to DFF45 located in the N terminus was required for DFF45 to inhibit CIDEA-induced apoptosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL340Hu01 Recombinant Cell Death Inducing DFFA Like Effector A (CIDEA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL340Hu01 Polyclonal Antibody to Cell Death Inducing DFFA Like Effector A (CIDEA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cell Death Inducing DFFA Like Effector A (CIDEA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Death Inducing DFFA Like Effector A (CIDEA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL340Mu01 Recombinant Cell Death Inducing DFFA Like Effector A (CIDEA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL340Mu01 Polyclonal Antibody to Cell Death Inducing DFFA Like Effector A (CIDEA) WB
Assay Kits n/a CLIA Kit for Cell Death Inducing DFFA Like Effector A (CIDEA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Death Inducing DFFA Like Effector A (CIDEA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Death Inducing DFFA Like Effector A (CIDEA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Death Inducing DFFA Like Effector A (CIDEA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Death Inducing DFFA Like Effector A (CIDEA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Death Inducing DFFA Like Effector A (CIDEA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Death Inducing DFFA Like Effector A (CIDEA) ELISA Kit Customized Service Offer
  1. "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor."EMBO J. 17:2526-2533(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cidea is associated with lipid droplets and insulin sensitivity in humans."Proc. Natl. Acad. Sci. U.S.A. 105:7833-7838(2008) [PubMed] [Europe PMC] [Abstract]
  3. "Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA."Am. J. Physiol. 297:E1395-E1413(2009) [PubMed] [Europe PMC] [Abstract]
  4. "Solution structure of the CIDE-N domain of human cell death activator CIDE-A."Submitted (AUG-2007) to the PDB data bank