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Centaurin Delta 3 (CENTd3)

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ARAP3; DRAG1; Arf-GAP With Rho-GAP Domain,ANK Repeat And PH Domain-Containing Protein 3

Centaurin Delta 3 (CENTd3)
CCC L323
HGNC 24097
MGI 2147274
PubMed 11804589
UniProt Q8WWN8
Wiki CENTD3
CENTd3 encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.
ARAP3 is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated ARF6 GAP both in vitro and in vivo and that both its ARF-GAP and RHO-GAP domains cooperate in mediating PI3K-dependent rearrangements in the cell cytoskeleton and cell shape.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centaurin Delta 3 (CENTd3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centaurin Delta 3 (CENTd3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centaurin Delta 3 (CENTd3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centaurin Delta 3 (CENTd3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centaurin Delta 3 (CENTd3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centaurin Delta 3 (CENTd3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centaurin Delta 3 (CENTd3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centaurin Delta 3 (CENTd3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centaurin Delta 3 (CENTd3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centaurin Delta 3 (CENTd3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centaurin Delta 3 (CENTd3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centaurin Delta 3 (CENTd3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centaurin Delta 3 (CENTd3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centaurin Delta 3 (CENTd3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centaurin Delta 3 (CENTd3) ELISA Kit Customized Service Offer
  1. "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices." Mol. Cell 9:95-108(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "GTPase signaling: bridging the GAP between ARF and Rho."Curr. Biol. 12:R360-R362(2002) [PubMed] [Europe PMC] [Abstract]
  5. "EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin."Proc. Natl. Acad. Sci. U.S.A. 101:17246-17251(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner."Cell. Signal. 19:1249-1257(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam."BMC Struct. Biol. 9:59-59(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]