≡

Centromere Protein O (CENPO)

[Edit]

CENP-O; ICEN36; MCM21R; Interphase centromere complex protein 36

Centromere Protein O (CENPO)
CCC L314
HGNC 28152
MGI 1923800
PubMed 21980299
UniProt Q9BU64
Wiki CENPO
CENPO is a subunit of a CENPH-CENPI-associated centromeric complex that targets CENPA to centromeres and is required for proper kinetochore function and mitotic progression.
CENPO as a component of the CENPH-CENPI centromeric complex. Deletion of Cenpo in a chicken B-cell line resulted in viable cells that grew more slowly than controls; knockout of CENPO in HeLa cells also reduced the rate of growth. Loss of CENPO in human and chicken cells did not alter the localization of other CENPH-CENPI centromeric complex components. Since cells deficient in CENPO were similar to those deficient in CENPP, CENPQ, and CENP50 (MLF1IP), Okada et al. (2006) suggested that these proteins form an accessory subcomplex within the CENPH-CENPI centromeric complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein O (CENPO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein O (CENPO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein O (CENPO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein O (CENPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein O (CENPO) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein O (CENPO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein O (CENPO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein O (CENPO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein O (CENPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein O (CENPO) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation."EMBO J. 25:4033-4049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The human CENP-A centromeric nucleosome-associated complex."Nat. Cell Biol. 8:458-469(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity."EMBO J. 26:5033-5047(2007) [PubMed] [Europe PMC] [Abstract]