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Centromere Protein N (CENPN)

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CENP-N; C16orf60; ICEN32; Interphase centromere complex protein 32

Centromere Protein N (CENPN)
CCC L313
HGNC 30873
MGI 1919405
PubMed 16622419
RGD 1310953
UniProt Q96H22
Wiki CENPN
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA replaces histone H3. CENPN is an additional factor required for centromere assembly.Epitope-tagged CENPN bound to centromeres throughout interphase and during mitosis. CENPM, CENPN, CENPT, and CENPU (MLF1IP), together with CENPC and CENPH , bound CENPA in a nucleosome-associated complex. Small interference RNA (siRNA)-mediated depletion of CENPN disrupted recruitment of the core complex, caused the loss of CENPM from centromeres, and increased the number of cells in mitosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein N (CENPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein N (CENPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein N (CENPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein N (CENPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein N (CENPN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein N (CENPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein N (CENPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein N (CENPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein N (CENPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein N (CENPN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein N (CENPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein N (CENPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein N (CENPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein N (CENPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein N (CENPN) ELISA Kit Customized Service Offer
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  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N."Nat. Cell Biol. 11:896-902(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]