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Centromere Protein C (CENPC)

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CENPC1; CENP-C; MIF2; hcp-4; ICEN7; Centromere autoantigen C; Interphase centromere complex protein 7

Centromere Protein C (CENPC)
CCC L309
HGNC 1854
MGI 99700
PubMed 20140237
RGD 1303061
UniProt Q03188
Wiki CENPC1
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.
The predicted 943-amino acid CENPC1 protein has an isoelectric point of 9.4 and a calculated molecular mass of 107 kD; its observed mass of 140 kD by SDS-PAGE is due to anomalous migration. The inactive centromere, lacking a constriction, also lacked CENPC. CENPC therefore seemed to be necessary for active centromeres, and the absence of CENPC appeared to be a marker of centromere inactivation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein C (CENPC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein C (CENPC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein C (CENPC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein C (CENPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein C (CENPC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein C (CENPC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein C (CENPC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein C (CENPC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein C (CENPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein C (CENPC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein C (CENPC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein C (CENPC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein C (CENPC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein C (CENPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein C (CENPC) ELISA Kit Customized Service Offer
  1. "CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate."Cell 70:115-125(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The human CENP-A centromeric nucleosome-associated complex."Nat. Cell Biol. 8:458-469(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres."Genome Biol. 8:R148.1-R148.19(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation."PLoS ONE 4:E5832-E5832(2009) [PubMed] [Europe PMC] [Abstract]
  10. "DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions."Hum. Mol. Genet. 18:3178-3193(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes."Cell 145:410-422(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]