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CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3)

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C53; HSF-27; IC53; LZAP; Ischemic Heart CDK5 Activator-Binding Protein C53; LXXLL/Leucine-Zipper-Containing ARF Binding Protein

CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3)
CCC L304
HGNC 18673
MGI 1933126
PubMed 17549666
UniProt Q96JB5
Wiki CDK5RAP3
CDK5RAP3binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.
CDK5RAP3 has 2 leucine zipper motifs, several putative phosphorylation and N-myristoylation sites, and no signal peptide. Northern blot analysis detected transcripts of 3.2 and 2.0 kb expressed in all normal tissues examined, with highest expression of the 3.2-kb transcript in peripheral blood leukocytes, liver, and kidney, and highest expression of the 2.0-kb transcript in heart. Both transcripts were expressed in all tumor cell lines examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) ELISA Kit Customized Service Offer
  1. "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart."Biochem. Biophys. Res. Commun. 294:161-166(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein."Cell Res. 13:83-91(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
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  6. "Cloning of three novel neuronal Cdk5 activator binding proteins."Gene 242:285-294(2000) [PubMed] [Europe PMC] [Abstract]
  7. "A novel LZAP-binding protein, NLBP, inhibits cell invasion."J. Biol. Chem. 285:12232-12240(2010) [PubMed] [Europe PMC] [Abstract]
  8. "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling."J. Biol. Chem. 285:15126-15136(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]