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Cell Division Cycle Protein 5 Like Protein (CDC5L)

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CEF1; PCDC5RP; hCDC5; CDC5; Pombe cdc5-related protein

Cell Division Cycle Protein 5 Like Protein (CDC5L)
CCC L302
HGNC 1743
MGI 1918952
PubMed 21385873
RGD 70892
UniProt Q99459
Wiki CDC5L
CDC5L shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.The putative 802-amino acid protein is significantly homologous to the S. pombe Cdc5 gene product and contains 2 tandem repeats of a helix-turn-helix DNA-binding motif with similarity to Myb-related proteins, 4 consensus nuclear localization signals, a proline-rich, hydrophobic region similar to known activation domains, and 28 potential sites for phosphorylation by intracellular kinases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 5 Like Protein (CDC5L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 5 Like Protein (CDC5L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 5 Like Protein (CDC5L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 5 Like Protein (CDC5L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 5 Like Protein (CDC5L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 5 Like Protein (CDC5L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 5 Like Protein (CDC5L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 5 Like Protein (CDC5L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 5 Like Protein (CDC5L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 5 Like Protein (CDC5L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 5 Like Protein (CDC5L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 5 Like Protein (CDC5L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 5 Like Protein (CDC5L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 5 Like Protein (CDC5L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 5 Like Protein (CDC5L) ELISA Kit Customized Service Offer
  1. "Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling."J. Biol. Chem. 272:5833-5837(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia."Genomics 49:218-229(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes."Mol. Cell. Biol. 18:4097-4108(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A cdc5+ homolog of a higher plant, Arabidopsis thaliana."Proc. Natl. Acad. Sci. U.S.A. 93:13371-13376(1996) [PubMed] [Europe PMC] [Abstract]
  9. "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry."J. Biol. Chem. 275:25411-25417(2000) [PubMed] [Europe PMC] [Abstract]
  10. "A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry."J. Biol. Chem. 273:4666-4671(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex."Nat. Genet. 20:46-50(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing."Proc. Natl. Acad. Sci. U.S.A. 96:13789-13794(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry."EMBO J. 19:6569-6581(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein."J. Cell Sci. 113:4523-4531(2000) [PubMed] [Europe PMC] [Abstract]
  15. "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing."J. Biol. Chem. 276:42370-42381(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  17. "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing."Biochem. Biophys. Res. Commun. 308:793-801(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing."Cell Cycle 7:1795-1803(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1."Mol. Cell 31:474-484(2008) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Molecular architecture of the human Prp19/CDC5L complex."Mol. Cell. Biol. 30:2105-2119(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  28. "CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31."J. Biol. Chem. 286:17091-17102(2011) [PubMed] [Europe PMC] [Abstract]
  29. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  30. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  31. "PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry."Mol. Cell 53:235-246(2014) [PubMed] [Europe PMC] [Abstract]
  32. "Solution structure of the MYB DNA-binding domain of human cell division cycle 5-like protein."Submitted (APR-2007) to the PDB data bank