Cluster Of Differentiation 180 (CD180)

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LY64; Ly78; RP105; Lymphocyte Antigen 64, Radioprotective 105kD

Cluster Of Differentiation 180 (CD180)
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.The cDNA encodes a 661-amino acid polypeptide containing a putative signal sequence, a single transmembrane region, and leucine-rich repeats in the extracellular domain. Northern blotting of human leukocyte cell lines showed that RP105 was expressed in some B cells and monocytes, but not in T cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL297Hu01 Recombinant Cluster Of Differentiation 180 (CD180) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL297Hu21 Monoclonal Antibody to Cluster Of Differentiation 180 (CD180) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 180 (CD180) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 180 (CD180) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 180 (CD180) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 180 (CD180) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 180 (CD180) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 180 (CD180) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 180 (CD180) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 180 (CD180) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 180 (CD180) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 180 (CD180) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 180 (CD180) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 180 (CD180) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)."Genomics 38:299-304(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "RP105 is associated with MD-1 and transmits an activation signal in human B cells."Blood 92:2815-2822(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family."J. Mol. Biol. 413:815-825(2011) [PubMed] [Europe PMC] [Abstract]