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Casitas B Lineage Lymphoma Proto-oncogene B (CBLB)

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RNF56; Ring Finger Protein 56; Cas-Br-M(Murine)Ecotropic Retroviral Transforming Sequence B; Signal transduction protein CBL-B

Casitas B Lineage Lymphoma Proto-oncogene B (CBLB)
CCC L279
HGNC 1542
MGI 2146430
PubMed 20453840
RGD 620535
UniProt Q13191
Wiki CBLB
CBLB cDNA encodes a predicted 982-amino acid protein. Like CBL, CBLB contains putative nuclear localization signal, zinc finger, leucine zipper, and proline-rich domains. RT-PCR analysis indicated that there are leucine zipper-negative alternatively spliced forms of CBLB detectable in breast cancer cell lines.
CBLB associates with FYN, FGR, and PLCG1 but not with the SH3 proteins NCK1, SPTA1, or EPS8.phosphorylation mediated by CD3Z, ZAP70, and LCK tyrosine kinases or by MAP kinases is not impaired by lack of CBLB. CBLB-deficient mice were also much more susceptible to experimental autoimmune encephalomyelitis, a model for multiple sclerosis, after immunization with myelin basic protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casitas B Lineage Lymphoma Proto-oncogene B (CBLB) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene."Oncogene 10:2367-2377(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation."Oncogene 15:2511-2520(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation."Oncogene 18:1147-1156(1999) [PubMed] [Europe PMC] [Abstract]
  9. "cbl-b inhibits epidermal growth factor receptor signaling."Oncogene 18:1855-1866(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells."J. Biol. Chem. 276:4872-4878(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex."J. Biol. Chem. 276:27677-27684(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells."Nat. Immunol. 2:870-875(2001) [PubMed] [Europe PMC] [Abstract]
  13. "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases."J. Biol. Chem. 277:39666-39672(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation."Oncogene 23:1645-1655(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b."Oncogene 23:7104-7115(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation."Sci. Signal. 2:RA30-RA30(2009) [PubMed] [Europe PMC] [Abstract]
  19. "The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme."J. Biol. Chem. 285:23687-23698(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Cbl promotes clustering of endocytic adaptor proteins."Nat. Struct. Mol. Biol. 12:972-979(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain."J. Biol. Chem. 281:38845-38853(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b."Mol. Cell 27:474-485(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Solution structure of RSGI RUH-065, a UBA domain from human cDNA."Submitted (MAY-2007) to the PDB data bank
  24. "Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide."Submitted (OCT-2010) to the PDB data bank