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Budding Uninhibited By Benzimidazoles 1B (BUB1B)

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BUBR1; Bub1A; MAD3L; SSK1; hBUBR1; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MAD3/BUB1-related protein kinase; Mitotic checkpoint kinase MAD3L

Budding Uninhibited By Benzimidazoles 1B (BUB1B)
CCC L277
HGNC 1149
MGI 1333889
PubMed 23154965
RGD 619791
UniProt O60566
Wiki BUB1B
BUB1B encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. The predicted BUB1B protein contains the conserved CD1 and CD2 domains that are found in yeast, human, and mouse BUB1; the human and mouse BUB1B proteins are 29% identical in these regions. CD1 directs kinetochore localization and binding to Bub3, and CD2 contains the kinase domain. Between CD1 and CD2, the BUB1B protein has a putative nuclear localization signal, which is present in human and mouse BUB1 but not in yeast BUB1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Budding Uninhibited By Benzimidazoles 1B (BUB1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Budding Uninhibited By Benzimidazoles 1B (BUB1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Budding Uninhibited By Benzimidazoles 1B (BUB1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Budding Uninhibited By Benzimidazoles 1B (BUB1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Budding Uninhibited By Benzimidazoles 1B (BUB1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Budding Uninhibited By Benzimidazoles 1B (BUB1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Budding Uninhibited By Benzimidazoles 1B (BUB1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Budding Uninhibited By Benzimidazoles 1B (BUB1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Budding Uninhibited By Benzimidazoles 1B (BUB1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Budding Uninhibited By Benzimidazoles 1B (BUB1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Budding Uninhibited By Benzimidazoles 1B (BUB1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Budding Uninhibited By Benzimidazoles 1B (BUB1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Budding Uninhibited By Benzimidazoles 1B (BUB1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Budding Uninhibited By Benzimidazoles 1B (BUB1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Budding Uninhibited By Benzimidazoles 1B (BUB1B) ELISA Kit Customized Service Offer
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  9. "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC."J. Cell Biol. 146:941-954(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Mad2-independent inhibition of APC/Cdc20 by the mitotic checkpoint protein BubR1."Dev. Cell 1:227-237(2001) [PubMed] [Europe PMC] [Abstract]
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  17. "Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1."Dev. Cell 13:663-676(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions."Genes Dev. 21:2205-2219(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1."J. Biol. Chem. 282:15217-15227(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit."J. Cell Biol. 183:667-680(2008) [PubMed] [Europe PMC] [Abstract]
  21. "SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis."Mol. Cell 29:729-741(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  23. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Depletion of BubR1 promotes premature centrosomal localization of cyclin B1 and accelerates mitotic entry."Cell Cycle 8:1754-1764(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E."Cell Cycle 8:2643-2649(2009) [PubMed] [Europe PMC] [Abstract]
  27. "BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis."EMBO J. 28:2077-2089(2009) [PubMed] [Europe PMC] [Abstract]
  28. "BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells."Oncogene 28:2806-2820(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  34. "Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome."Am. J. Med. Genet. A 140:358-367(2006) [PubMed] [Europe PMC] [Abstract]
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