Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A)

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FREUD-1; MRT3; AKI1; Mental Retardation,Nonsyndromic,Autosomal Recessive 3; Five prime repressor element under dual repression-binding 1; Akt kinase-interacting protein 1

Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A)
The deduced 950-amino acid protein contains a C2 domain and a DM14 motif. A deduced 338-amino acid isoform does not contain the DM motif. In situ hybridization of day 12 mouse embryos detected Cc2d1a throughout the ventricular zone and developing cortical plate and ganglionic eminences.
By embryonic day 16, expression was strongest in the cortical plate; from postnatal day 3 into adulthood, expression was strongest in the cerebral cortex and hippocampus, particularly in hippocampal region CA3. Western blot analysis of normal human lymphoblastoid cells detected CC2D1A at an apparent molecular mass of 104 kD. Immunohistochemical analysis detected CC2D1a in the cytoplasm of human osteosarcoma cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL275Hu01 Recombinant Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL275Hu01 Polyclonal Antibody to Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) WB; IHC; ICC; IP.
MAL275Hu21 Monoclonal Antibody to Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) WB; IHC; ICC; IP.
Assay Kits SEL275Hu ELISA Kit for Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) ELISA Kit Customized Service Offer
  1. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation."J. Med. Genet. 43:203-210(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Mitotic phosphorylation of Aki1 at Ser208 by cyclin B1-Cdk1 complex."Biochem. Biophys. Res. Commun. 393:872-876(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]