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Bruno Like 4, RNA Binding Protein (BRUNOL4)

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CELF4; CUG-BP And ETR-3 Like Factor 4; RNA-binding protein BRUNOL-4; CUGBP Elav-like family member 4

Bruno Like 4, RNA Binding Protein (BRUNOL4)
CCC L270
HGNC 14015
MGI 1932407
PubMed 10893231
RGD 1307630
UniProt Q9BZC1
Wiki BRUNOL4
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Several transcript variants encoding different isoforms have been found for this gene, but their full-length nature has not been determined yet.In addition to the 3 RRMs, the deduced 486-amino acid CELF4 protein contains multiple potential phosphorylation sites and a consensus nuclear localization signal near the C terminus. Western blot analysis of adult mouse tissues detected multiple CELF4 isoforms that were expressed predominantly in skeletal muscle and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bruno Like 4, RNA Binding Protein (BRUNOL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bruno Like 4, RNA Binding Protein (BRUNOL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bruno Like 4, RNA Binding Protein (BRUNOL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bruno Like 4, RNA Binding Protein (BRUNOL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bruno Like 4, RNA Binding Protein (BRUNOL4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bruno Like 4, RNA Binding Protein (BRUNOL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bruno Like 4, RNA Binding Protein (BRUNOL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bruno Like 4, RNA Binding Protein (BRUNOL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bruno Like 4, RNA Binding Protein (BRUNOL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bruno Like 4, RNA Binding Protein (BRUNOL4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bruno Like 4, RNA Binding Protein (BRUNOL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bruno Like 4, RNA Binding Protein (BRUNOL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bruno Like 4, RNA Binding Protein (BRUNOL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bruno Like 4, RNA Binding Protein (BRUNOL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bruno Like 4, RNA Binding Protein (BRUNOL4) ELISA Kit Customized Service Offer
  1. "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing."Mol. Cell. Biol. 21:1285-1296(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator."J. Biol. Chem. 275:28583-28592(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of murine Brunol4, a new member of the elav/bruno family."Cytogenet. Genome Res. 97:254-260(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein."RNA 9:443-456(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors."J. Neurochem. 88:1078-1090(2004) [PubMed] [Europe PMC] [Abstract]
  8. "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo."Nucleic Acids Res. 32:1232-1241(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of CELF splicing activation and repression domains in vivo."Nucleic Acids Res. 33:2769-2780(2005) [PubMed] [Europe PMC] [Abstract]
  10. "ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I."J. Neurosci. Res. 84:852-859(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of RNA-binding domain in Bruno-like 4 RNA-binding protein."Submitted (OCT-2006) to the PDB data bank