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POU Domain Class 4 Transcription Factor 3 (POU4F3)

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BRN3C; DFNA15; Brain-specific homeobox/POU domain protein 3C

POU Domain Class 4 Transcription Factor 3 (POU4F3)
CCC L269
HGNC 9220
MGI 102523
PubMed 9506947
RGD 1310459
UniProt Q15319
Wiki POU4F3
POU4F3 encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15.
The BRN3C gene encodes a 338-amino acid polypeptide that contains several identifiable motifs, including a POU domain. Although its splicing pattern is identical to that of BRN3A and BRN3B, the 3 members of the BRN3 family are unlinked.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant POU Domain Class 4 Transcription Factor 3 (POU4F3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to POU Domain Class 4 Transcription Factor 3 (POU4F3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to POU Domain Class 4 Transcription Factor 3 (POU4F3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for POU Domain Class 4 Transcription Factor 3 (POU4F3) CLIA Kit Customized Service Offer
n/a ELISA Kit for POU Domain Class 4 Transcription Factor 3 (POU4F3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant POU Domain Class 4 Transcription Factor 3 (POU4F3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to POU Domain Class 4 Transcription Factor 3 (POU4F3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to POU Domain Class 4 Transcription Factor 3 (POU4F3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for POU Domain Class 4 Transcription Factor 3 (POU4F3) CLIA Kit Customized Service Offer
n/a ELISA Kit for POU Domain Class 4 Transcription Factor 3 (POU4F3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant POU Domain Class 4 Transcription Factor 3 (POU4F3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to POU Domain Class 4 Transcription Factor 3 (POU4F3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to POU Domain Class 4 Transcription Factor 3 (POU4F3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for POU Domain Class 4 Transcription Factor 3 (POU4F3) CLIA Kit Customized Service Offer
n/a ELISA Kit for POU Domain Class 4 Transcription Factor 3 (POU4F3) ELISA Kit Customized Service Offer
  1. "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons."J. Neurosci. 15:4762-4785(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans."Science 279:1950-1954(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding."Hum. Mutat. 29:545-554(2008) [PubMed] [Europe PMC] [Abstract]