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Transcription Factor IIIB 90kDa (TFIIIB90)

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BRF1; BRF; GTF3B; TAF3B2; TAF3C; TAFIII90; TF3B90; hBRF; B-related factor 1; BRF1 Homolog,Subunit Of RNA polymerase III Transcription Initiation Factor IIIB

Transcription Factor IIIB 90kDa (TFIIIB90)
CCC L264
HGNC 11551
MGI 1919558
PubMed 7624363
RGD 1311158
UniProt Q92994
Wiki BRF1
BRF1 encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Three alternatively spliced variants encoding three different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. A transcript encoding a fourth isoform has not yet been completely characterized.Sequence analysis revealed that the 675-amino acid TAF3B2 protein contains a high mobility group protein-2 (HMG2)-related region in the highly charged C-terminal half of the protein and a sequence related to GTF2B in the N terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor IIIB 90kDa (TFIIIB90) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor IIIB 90kDa (TFIIIB90) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor IIIB 90kDa (TFIIIB90) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor IIIB 90kDa (TFIIIB90) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor IIIB 90kDa (TFIIIB90) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor IIIB 90kDa (TFIIIB90) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor IIIB 90kDa (TFIIIB90) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor IIIB 90kDa (TFIIIB90) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor IIIB 90kDa (TFIIIB90) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor IIIB 90kDa (TFIIIB90) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor IIIB 90kDa (TFIIIB90) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor IIIB 90kDa (TFIIIB90) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor IIIB 90kDa (TFIIIB90) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor IIIB 90kDa (TFIIIB90) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor IIIB 90kDa (TFIIIB90) ELISA Kit Customized Service Offer
  1. "Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains."Proc. Natl. Acad. Sci. U.S.A. 92:7026-7030(1995) [PubMed] [Europe PMC] [Abstract]
  2. "RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB."Mol. Cell. Biol. 16:7031-7042(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Alternatively spliced hBRF variants function at different RNA polymerase III promoters."EMBO J. 19:4134-4143(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo."EMBO J. 22:5841-5850(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies." Genome Res. 25:155-166(2015) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]