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Bromodomain PHD Finger Transcription Factor (BPTF)

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FAC1; FALZ; Fetal Alzheimer Antigen; Nucleosome-remodeling factor subunit BPTF; Fetal Alz-50 clone 1 protein; Bromodomain and PHD finger-containing transcription factor

Bromodomain PHD Finger Transcription Factor (BPTF)
CCC L263
HGNC 3581
MGI 2444008
PubMed 18974875
UniProt Q12830
Wiki BPTF
BPTF was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain PHD Finger Transcription Factor (BPTF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain PHD Finger Transcription Factor (BPTF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain PHD Finger Transcription Factor (BPTF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain PHD Finger Transcription Factor (BPTF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain PHD Finger Transcription Factor (BPTF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain PHD Finger Transcription Factor (BPTF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain PHD Finger Transcription Factor (BPTF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain PHD Finger Transcription Factor (BPTF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain PHD Finger Transcription Factor (BPTF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain PHD Finger Transcription Factor (BPTF) ELISA Kit Customized Service Offer
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  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
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  7. "DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation."Biochem. Biophys. Res. Commun. 260:785-789(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator."J. Biol. Chem. 274:35262-35268(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity."Biochemistry 39:3206-3215(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein."Biochemistry 43:12113-12122(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling."Nature 442:86-90(2006) [PubMed] [Europe PMC] [Abstract]
  13. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF."Nature 442:91-95(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger."Mol. Cell 28:677-691(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Histone recognition and large-scale structural analysis of the human bromodomain family."Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]