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Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1)

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ZA2G; ZAG

Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1)
CCC L231
HGNC 910
MGI 103163
PubMed 17724461
RGD 2187
UniProt P25311
Wiki AZGP1
AZGP1 expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium. In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.
AZGP1 gene spans over 9.7 kb and that its overall organization and nucleotide sequence resemble those of the first 4 exons of class I MHC genes. However, it differs from those genes by its lack of coding information for transmembrane and cytoplasmic domains typical of MHC genes, which is consistent with its presence as a soluble protein in various physiologic and pathologic fluids. The human genome also contains a putative AZGP1 pseudogene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL231Hu01 Recombinant Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPL231Hu02 Recombinant Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL231Hu01 Polyclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
PAL231Hu02 Polyclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
LAL231Hu71 Biotin-Linked Polyclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC.
MAL231Hu29 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Hu21 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Hu27 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Hu24 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Hu25 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Hu22 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Hu23 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
Assay Kits SEL231Hu ELISA Kit for Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCL231Hu CLIA Kit for Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL231Mu01 Recombinant Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPL231Mu02 Recombinant Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL231Mu01 Polyclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
LAL231Mu71 Biotin-Linked Polyclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC.
PAL231Mu02 Polyclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
Assay Kits SEL231Mu ELISA Kit for Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL231Ra01 Recombinant Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL231Ra01 Polyclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Ra21 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB
MAL231Ra22 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Ra23 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Ra24 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB
MAL231Ra29 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Ra25 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
MAL231Ra27 Monoclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) WB; IHC; ICC; IP.
Assay Kits SEL231Ra ELISA Kit for Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues."FEBS Lett. 290:247-249(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein."Biochemistry 32:12968-12976(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes."Genomics 18:575-587(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene."Biochem. Biophys. Res. Commun. 177:696-703(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens."Proc. Natl. Acad. Sci. U.S.A. 85:679-683(1988) [PubMed] [Europe PMC] [Abstract]
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Biochemical characterization and crystallization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog."Proc. Natl. Acad. Sci. U.S.A. 94:4626-4630(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins."J. Biol. Chem. 276:35008-35013(2001) [PubMed] [Europe PMC] [Abstract]
  12. "A proteomic analysis of human bile."Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  18. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules."Science 283:1914-1919(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein."J. Struct. Biol. 148:205-213(2004) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma."J. Mol. Biol. 384:663-672(2008) [PubMed] [Europe PMC] [Abstract]