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Autophagy Related Protein 9A (ATG9A)

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APG9L1; APG9 Autophagy 9-Like 1

Autophagy Related Protein 9A (ATG9A)
CCC L225
HGNC 22408
MGI 2138446
PubMed 22275429
RGD 1310450
UniProt Q7Z3C6
Wiki ATG9A
The deduced 839-amino acid human protein has an APG9-like domain and predicted transmembrane domains. Northern blot and RT-PCR analysis detected APG9L1 in all tissues examined. Mouse Apg9l1 was also widely expressed. Time-lapse imaging showed that mouse Apg9l1 colocalized with the autophagosome membrane marker Lc3 (MAP1LC3A) in transfected COS-7 cells.
Knockdown of APG9L1 in HeLa cells reduced starvation-induced autophagosome formation and that mouse Apg9l2 (ATG9B) complemented the loss of APG9L1. APG9L1 is essential for mammalian autophagy and that APG9L2 is complementary to APG9L1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autophagy Related Protein 9A (ATG9A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autophagy Related Protein 9A (ATG9A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autophagy Related Protein 9A (ATG9A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autophagy Related Protein 9A (ATG9A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autophagy Related Protein 9A (ATG9A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autophagy Related Protein 9A (ATG9A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autophagy Related Protein 9A (ATG9A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autophagy Related Protein 9A (ATG9A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autophagy Related Protein 9A (ATG9A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autophagy Related Protein 9A (ATG9A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autophagy Related Protein 9A (ATG9A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autophagy Related Protein 9A (ATG9A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autophagy Related Protein 9A (ATG9A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autophagy Related Protein 9A (ATG9A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autophagy Related Protein 9A (ATG9A) ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast."J. Biol. Chem. 280:18283-18290(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes."J. Cell Sci. 119:3888-3900(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism."Mol. Cell. Biol. 29:157-171(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP."EMBO J. 29:27-40(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment."J. Biol. Chem. 285:1371-1383(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains."J. Histochem. Cytochem. 58:443-453(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy."Autophagy 7:61-73(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]