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Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP)

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ATF7IP1; MCAF; p621; Mbd1-Containing Chromatin-Associated Factor 1; ATF-interacting protein; ATF7-interacting protein; ATFa-associated modulator

Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP)
CCC L220
HGNC 20092
MGI 1858965
PubMed 24464130
RGD 1306030
UniProt Q6VMQ6
Wiki ATF7IP
ATF7IP belongs to the MCAF family.Interacts with MBD1; the interaction is enhanced when MBD1 is sumoylated. Probably forms a complex with SETDB1 and MBD1. Interacts with SUMO ubiquitin-like proteins (SUMO1, SUNO2 and SUMO3), with a preference for SUMO2 and SUMO3. Interacts with SP1, ATF7 and ZHX1. Interacts with Epstein-Barr virus BRLF1/Rta protein, leading to promote and regulate host genes in Epstein- Barr virus-infected cells.Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activating Transcription Factor 7 Interacting Protein 1 (ATF7IP) ELISA Kit Customized Service Offer
  1. "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression."Mol. Cell 12:475-487(2003) [PubMed] [Europe PMC] [Abstract]
  2. "MCAF mediates MBD1-dependent transcriptional repression."Mol. Cell. Biol. 23:2834-2843(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening."Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3."Biochem. J. 373:167-178(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins."J. Biol. Chem. 280:13928-13935(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1."Nucleic Acids Res. 33:6528-6539(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation."J. Biol. Chem. 281:23180-23190(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity."J. Biol. Chem. 284:5165-5174(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Structure of the small ubiquitin-like modifier (SUMO)-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3."J. Biol. Chem. 283:35966-35975(2008) [PubMed] [Europe PMC] [Abstract]