≡

Absent, Small Or Homeotic 2 Like Protein (ASH2L)

[Edit]

ASH2; ASH2L1; ASH2L2; Bre2; ASH2-like protein

Absent, Small Or Homeotic 2 Like Protein (ASH2L)
CCC L217
HGNC 744
MGI 1344416
PubMed 23239880
RGD 1305632
UniProt Q9UBL3
Wiki ASH2L
A full-length ASH2L cDNA encoding a deduced 628-amino acid protein with 93.9% amino acid sequence identity to mouse Ash2l and 45.4% identity to Drosophila ash2. ASH2L contains a predicted PHD zinc finger domain, a putative bipartite nuclear localization signal, potential N-linked glycosylation sites, and potential tyrosine kinase phosphorylation sites. Northern blot analysis detected an approximately 2.6-kb ASH2L transcript in human adult and fetal tissues.
ASH2L was ubiquitously expressed, but it was predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. ASH2L functions as a transcriptional regulator.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Absent, Small Or Homeotic 2 Like Protein (ASH2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Absent, Small Or Homeotic 2 Like Protein (ASH2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Absent, Small Or Homeotic 2 Like Protein (ASH2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Absent, Small Or Homeotic 2 Like Protein (ASH2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Absent, Small Or Homeotic 2 Like Protein (ASH2L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Absent, Small Or Homeotic 2 Like Protein (ASH2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Absent, Small Or Homeotic 2 Like Protein (ASH2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Absent, Small Or Homeotic 2 Like Protein (ASH2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Absent, Small Or Homeotic 2 Like Protein (ASH2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Absent, Small Or Homeotic 2 Like Protein (ASH2L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Absent, Small Or Homeotic 2 Like Protein (ASH2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Absent, Small Or Homeotic 2 Like Protein (ASH2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Absent, Small Or Homeotic 2 Like Protein (ASH2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Absent, Small Or Homeotic 2 Like Protein (ASH2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Absent, Small Or Homeotic 2 Like Protein (ASH2L) ELISA Kit Customized Service Offer
  1. "ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines."J. Mol. Med. 79:399-405(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of ASH2L and ash2l, human and mouse homologs of the Drosophila ash2 gene."Cytogenet. Cell Genet. 84:167-172(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."Genes Dev. 17:896-911(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus."Mol. Cell 13:587-597(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."Mol. Cell. Biol. 24:5639-5649(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
  9. "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex."J. Biol. Chem. 280:41725-41731(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex."J. Biol. Chem. 282:13419-13428(2007) [PubMed] [Europe PMC] [Abstract]
  11. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."Mol. Cell. Biol. 28:609-618(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]
  14. "On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex."J. Biol. Chem. 284:24242-24256(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes."J. Biol. Chem. 286:12234-12244(2011) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding."EMBO Rep. 12:797-803(2011) [PubMed] [Europe PMC] [Abstract]