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Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2)

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Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2)
CCC L214
HGNC 16012
MGI 1929743
PubMed 12076535
RGD 1306414
UniProt Q96Q27
Wiki ASB2
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation.
ASB2 is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat And SOCS Box Containing Protein 2 (ASB2) ELISA Kit Customized Service Offer
  1. "ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells."FEBS Lett. 505:223-228(2001) [PubMed] [Europe PMC] [Abstract]
  2. "ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells."J. Biol. Chem. 277:218-224(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4."Gene 258:31-41(2000) [PubMed] [Europe PMC] [Abstract]
  8. "ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes."FEBS Lett. 579:6796-6802(2005) [PubMed] [Europe PMC] [Abstract]
  9. "ASB2 is an elongin BC-interacting protein that can assemble with cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex."J. Biol. Chem. 280:5468-5474(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation."Cell Death Differ. 16:921-932(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Functional and structural insights into ASB2alpha, a novel regulator of integrin-dependent adhesion of hematopoietic cells."J. Biol. Chem. 286:30571-30581(2011) [PubMed] [Europe PMC] [Abstract]
  12. "ASB2alpha, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain."J. Biol. Chem. 288:32093-32105(2013) [PubMed] [Europe PMC] [Abstract]