Hairless (HR)

[Edit]

AU; ALUNC; H; Lysine-specific demethylase hairless

Hairless (HR)
HR encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hairless (HR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hairless (HR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hairless (HR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hairless (HR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hairless (HR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hairless (HR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hairless (HR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hairless (HR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hairless (HR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hairless (HR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hairless (HR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hairless (HR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hairless (HR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hairless (HR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hairless (HR) ELISA Kit Customized Service Offer
  1. "Alopecia universalis associated with a mutation in the human hairless gene."Science 279:720-724(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family."Genomics 56:141-148(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia."Hum. Mol. Genet. 7:1671-1679(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis." Nat. Genet. 41:228-233(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Hairless is a histone H3K9 demethylase."FASEB J. 28:1534-1542(2014) [PubMed] [Europe PMC] [Abstract]
  7. "A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers."Am. J. Hum. Genet. 63:984-991(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Variant 1859G-->A (Arg620Gln) of the 'hairless' gene: absence of association with papular atrichia or androgenic alopecia."Am. J. Hum. Genet. 69:235-237(2001) [PubMed] [Europe PMC] [Abstract]
  9. "A novel missense mutation affecting the human hairless thyroid receptor interacting domain 2 causes congenital atrichia."J. Invest. Dermatol. 119:920-922(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of a novel U2HR mutation in a Korean woman with Marie Unna hereditary hypotrichosis."Int. J. Dermatol. 53:1358-1361(2014) [PubMed] [Europe PMC] [Abstract]