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N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3)

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APBA2BP; NIP1; EFCBP3; SYTIP2; XB51; Amyloid beta A4 protein-binding family A member 2-binding protein; Neuronal calcium-binding protein 3; Nek2-interacting protein 1

N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3)
CCC L200
HGNC 15851
MGI 1861721
PubMed 14697346
RGD 1310124
UniProt Q96P71
Wiki NECAB3
NECAB3 interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation.
The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. The deduced 273-amino acid human protein contains a leucine zipper-like motif and shares 75.5% homology to its mouse ortholog.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3) ELISA Kit Customized Service Offer
  1. "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern."Neuroscience 112:51-63(2002) [PubMed] [Europe PMC] [Abstract]
  2. "NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi."Exp. Cell Res. 292:393-402(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein."J. Biol. Chem. 275:23134-23138(2000) [PubMed] [Europe PMC] [Abstract]