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Ankylosis, Progressive Homolog (ANKH)

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ANK; CCAL2; CMDJ; CPPDD; HANK; MANK

Ankylosis, Progressive Homolog (ANKH)
CCC L195
HGNC 15492
MGI 3045421
PubMed 21102543
RGD 619925
UniProt Q9HCJ1
ANKH encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Mutation at the mouse 'progressive ankylosis' (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. The human homolog is virtually identical to the mouse protein and ANKH-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.The human ANK gene is virtually identical to mouse ank, with only 9 amino acid differences over a 492-amino acid protein. There are 3 potential N-linked glycosylation sites and multiple putative phosphorylation sites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankylosis, Progressive Homolog (ANKH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankylosis, Progressive Homolog (ANKH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankylosis, Progressive Homolog (ANKH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankylosis, Progressive Homolog (ANKH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankylosis, Progressive Homolog (ANKH) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankylosis, Progressive Homolog (ANKH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankylosis, Progressive Homolog (ANKH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankylosis, Progressive Homolog (ANKH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankylosis, Progressive Homolog (ANKH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankylosis, Progressive Homolog (ANKH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankylosis, Progressive Homolog (ANKH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankylosis, Progressive Homolog (ANKH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankylosis, Progressive Homolog (ANKH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankylosis, Progressive Homolog (ANKH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankylosis, Progressive Homolog (ANKH) ELISA Kit Customized Service Offer
  1. "Role of the mouse ank gene in control of tissue calcification and arthritis."Science 289:265-270(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK."Am. J. Hum. Genet. 68:1321-1326(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia."Nat. Genet. 28:37-41(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in ANKH cause chondrocalcinosis."Am. J. Hum. Genet. 71:933-940(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH."Am. J. Hum. Genet. 71:985-991(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in the amino terminus of ANKH in two US families with calcium pyrophosphate dihydrate crystal deposition disease."Arthritis Rheum. 48:2627-2631(2003) [PubMed] [Europe PMC] [Abstract]