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Anaphase Promoting Complex Subunit 7 (ANAPC7)

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APC7; Cyclosome subunit 7

Anaphase Promoting Complex Subunit 7 (ANAPC7)
CCC L190
HGNC 17380
MGI 1929711
PubMed 20937555
RGD 1311927
UniProt Q9UJX3
Wiki ANAPC7
APC7 is a deduced 565-amino acid protein.The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8).
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anaphase Promoting Complex Subunit 7 (ANAPC7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anaphase Promoting Complex Subunit 7 (ANAPC7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anaphase Promoting Complex Subunit 7 (ANAPC7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anaphase Promoting Complex Subunit 7 (ANAPC7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anaphase Promoting Complex Subunit 7 (ANAPC7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anaphase Promoting Complex Subunit 7 (ANAPC7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anaphase Promoting Complex Subunit 7 (ANAPC7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anaphase Promoting Complex Subunit 7 (ANAPC7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anaphase Promoting Complex Subunit 7 (ANAPC7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anaphase Promoting Complex Subunit 7 (ANAPC7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anaphase Promoting Complex Subunit 7 (ANAPC7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anaphase Promoting Complex Subunit 7 (ANAPC7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anaphase Promoting Complex Subunit 7 (ANAPC7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anaphase Promoting Complex Subunit 7 (ANAPC7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anaphase Promoting Complex Subunit 7 (ANAPC7) ELISA Kit Customized Service Offer
  1. "Identification of a cullin homology region in a subunit of the anaphase-promoting complex."Science 279:1219-1222(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7."J. Biol. Chem. 284:15137-15146(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular architecture and mechanism of the anaphase-promoting complex."Nature 513:388-393(2014) [PubMed] [Europe PMC] [Abstract]