Amyotrophic Lateral Sclerosis 2 (ALS2)
[Edit]ALS2CR6; ALSJ; IAHSP; PLSJ; Alsin; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein
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ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases.
The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Amyotrophic Lateral Sclerosis 2 (ALS2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Amyotrophic Lateral Sclerosis 2 (ALS2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Amyotrophic Lateral Sclerosis 2 (ALS2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Amyotrophic Lateral Sclerosis 2 (ALS2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Amyotrophic Lateral Sclerosis 2 (ALS2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Amyotrophic Lateral Sclerosis 2 (ALS2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Amyotrophic Lateral Sclerosis 2 (ALS2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Amyotrophic Lateral Sclerosis 2 (ALS2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Amyotrophic Lateral Sclerosis 2 (ALS2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Amyotrophic Lateral Sclerosis 2 (ALS2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Amyotrophic Lateral Sclerosis 2 (ALS2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Amyotrophic Lateral Sclerosis 2 (ALS2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Amyotrophic Lateral Sclerosis 2 (ALS2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Amyotrophic Lateral Sclerosis 2 (ALS2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Amyotrophic Lateral Sclerosis 2 (ALS2) | ELISA Kit Customized Service Offer |
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- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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