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Aldo Keto Reductase Family 1, Member C4 (AKR1C4)

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CDR; 3-alpha-HSD; C11; CHDR; DD4; HAKRA; Chlordecone Reductase; 3-Alpha Hydroxysteroid Dehydrogenase,Type I; Dihydrodiol Dehydrogenase 4

Aldo Keto Reductase Family 1, Member C4 (AKR1C4)
CCC L186
HGNC 387
MGI 2653678
PubMed 21570127
UniProt P17516
Wiki AKR1C4
AKR1C4 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.The predicted 323-amino acid HAKR proteins share more than 85% identity. Northern blot analysis revealed that HAKRa is expressed as a major 1.4-kb mRNA and a minor 3.5-kb mRNA in liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member C4 (AKR1C4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member C4 (AKR1C4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member C4 (AKR1C4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member C4 (AKR1C4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member C4 (AKR1C4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member C4 (AKR1C4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member C4 (AKR1C4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member C4 (AKR1C4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member C4 (AKR1C4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member C4 (AKR1C4) ELISA Kit Customized Service Offer
  1. "Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase."J. Steroid Biochem. Mol. Biol. 46:673-679(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases."J. Biol. Chem. 270:20162-20168(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans."J. Steroid Biochem. Mol. Biol. 53:41-46(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver."Pharmacogenetics 9:763-771(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes."Genes Cells 5:111-125(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution."J. Clin. Endocrinol. Metab. 86:841-846(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase."Biochemistry 29:1080-1087(1990) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder."Biochem. J. 299:545-552(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Human hepatic 3 alpha-hydroxysteroid dehydrogenase: possible identity with human hepatic chlordecone reductase."Biochem. Biophys. Res. Commun. 187:760-766(1992) [PubMed] [Europe PMC] [Abstract]
  12. "Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation."Am. J. Hum. Genet. 89:201-218(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (AKR1C4) complexed with NADP+."Submitted (FEB-2006) to the PDB data bank